Are diabetes and dengue linked?

As the burden of non-communicable disease in low- and middle-income countries increases alongside a high incidence of infection, it is important to understand the links between the different disease groups in order to monitor and control their prevalence. In recent years, increasing numbers of older people have been affected by dengue – an infection that primarily affected children in the past – suggesting that age-related comorbidities could affect dengue pathogenesis.

Now, a systematic review and meta-analysis has been conducted to evaluate associations between diabetes and dengue severity. Analyzing five case-control studies, the authors showed that diabetes is associated with increased risk for severe dengue infection.

While the authors caution that available evidence is limited, and recommend that further studies are required, these findings indicate a possible link between the two diseases. The results suggest that diabetic patients with fever who live in an area affected by dengue should seek confirmation of dengue infection as soon as possible.

htun等。，PLO被忽视的热带疾病

对早期高血压的新见解

Primary aldosteronism(PA) is a rare hormonal disorder leading to early-onset hypertension. Genetic factors are known to play a role in the development of the condition, but the underlying causes are not completely understood.

Now, a new genetic mutation associated with PA has been identified. The researchers carried out exome sequencing of 40 individuals with PA, and found that five of them shared the same mutation in theCACNA1Hgene, which codes for a calcium channel expressed in cells of the adrenal gland.

在功能性电生理实验中，带有突变的钙通道更有可能开放，并且需要更长的时间才能停用，从而导致肾上腺中醛固酮的产生较大。

综上所述，这些发现为与PA相关的高血压的发病机理提供了新的见解，并表明钙通道可以代表该疾病的治疗靶标。

Scholl等。, eLife

Trial registration and primary outcome changes

临床试验是在可以在诊所中定期使用新疗法之前评估新疗法有效性的金标准方法。临床试验的注册是此类研究良好行为的非常重要的一步。但是，以前的研究表明，注册了大量试验clinicaltrials.govhave had the primary outcomes changed after registration and completion.

To investigate changes in trial registration further, a cross-sectional analysis of over 13,000 trials registered on clinicaltrials.gov was conducted, in an extension of a2014年研究。发现在试验完成后发生的主要结果的变化与研究报告的研究相关。

Together with other studies, this work emphasizes the need for transparent and accurate trial registry information, and quality control procedures to ensure that trials are reported correctly.

Ramagopalan等。,F1000研究

运动和乳腺癌风险：亚型的影响？

It is well-established that physical activity is negatively associated with breast cancer risk, but whether this link is modified by breast cancer subtype is not well-understood.

In an analysis of data from the population-basedWomen’s Contraceptive and Reproductive Experiences Study，来自美国和挪威的研究人员研究了乳腺癌的不同亚型（由雌激素受体（ER），孕酮受体（PR），人表皮生长因子受体2（HER2）和P53定义的不同亚型 - 与与与锻炼。

Self-reported physical activity was inversely associated with ER-positive and HER2-negative breast cancer, but not with the other subtypes. The authors conclude that exercise reduces the risk of breast cancers that do not express HER2, which provides new insights into the mechanisms linking exercise and breast cancer risk.

嘛等。，癌症医学

嘛naging psoriatic arthritis

Psoriatic arthritis是一种炎症性关节炎，可能发生在皮肤病患者中。存在许多管理该病的临床指南，但是使用疾病改良剂治疗银屑病关节炎的证据基础尚不清楚。

为了解决这一差距，已经进行了对合成药物或生物制剂作用的随机对照试验的系统综述。这些试验中的终点改善了银屑病关节炎的肌肉骨骼结局。最终分析中包括了28次试验，表明常规甲氨蝶呤，西克孢霉素和磺胺丙嗪不能改善预后，但左氟胺显示出较小的阳性作用。

较新的合成疾病改良剂（包括apremilast和各种单克隆抗体）显示出一些好处，但作者警告说，有限的证据可用于新药物。

这项系统综述的结果表明，常规的调整剂对治疗银屑病关节炎没有明显的好处，但是更新的生物学剂可能更有效。作者建议可能有必要审查银屑病关节炎治疗的指南，强调用于类风湿关节炎的治疗策略不一定是银屑病关节炎的有效疗法。

Kingsley and Scott, Psoriasis: Targets and Therapy