Latest advances in respiratory medicine from the British Thoracic Society 2013 meeting

Respiratory diseases are one of the major chronic diseases and considered by the World Health Organization (WHO)to cause60% of mortality worldwide。Significant research is being carried out on the diagnosis, treatment, management and care of patients with lung conditions. Clinical and scientific research on these specific topics were discussed at the recent英国胸腔会议(BTS 2013),哪里BMC Medicine加入了2,100多名代表,聆听该领域的新发展。

强调了几次临床试验会议连续正气道((CPAP) therapy for阻塞性睡眠呼吸暂停(OSA)。伦敦MRC临床试验部门的丹尼尔·布拉顿(Daniel Bratton)描述了对随机临床试验的系统综述,显示CPAP治疗可降低OSA的严重性和嗜睡。但是,除非每晚使用CPAP超过4个小时,否则CPAP治疗对最低症状的OSA患者的血压没有有益的影响。针对其他条件的临床试验,例如COPD还通过一项试点研究进行了讨论neuromuscular electrical stimulation(nm)和低强度symptom-limited锻炼((LISLE) being more effective in improving daily living activities and exercise tolerance. However, the cost of equipment and specialized staff for delivery of this individualized therapy must be weighed against the clinical benefits.

还强调了其他新颖的分层方法,并通过出色的表现。斯图尔特·埃尔伯恩(Stuart Elborn),贝尔法斯特皇后大学感染与免疫中心主任,他描述了临床试验证据ivacaftor,第一类新型CTFR计算机,用于治疗患者cystic fibrosishaving the G551D mutation. A第三阶段试验目前正在研究iVacaftor与另一种潜在疗法VX-809联合使用最常见的突变Delta F508患者的作用。继续以肺部疾病的治疗方法为主题,整个研讨会致力于发现新的治疗方法特发性肺纤维化((IPF), a lung condition with a high unmet medical need.Luca Richeldi描述了对干扰素γ(IFN-γ)的III期试验,波森坦,,,,macitentanandPirfenidonefor the treatment of IPF and emphasized the need for better endpoints and design of clinical trials. Robert Strieter who is the Global Head of Translational Medicine for Respiratory at Novartis Institutes for BioMedical Research, discussed biomarker development and translational research in IPF and how key collaborations with academia, health professionals, pharmaceutical industry and patients would help achieve this.

To mark the 20Th周年纪念日Cochrane collaboration发生了各种活动,包括发射有关Cochrane方法论的文章收藏。BTS 2013上的整个研讨会重点介绍了20年来发表的Cochrane呼吸评论,并描述了Archie Cochrane在呼吸医学以及Cochrane系统评价如何促进英国诊断和监测指南。此外,苏黎世大学的COPD和Milo Puhan的处理已经发表了几项Cochrane评论,强调了在临床试验中需要对福利和伤害评估的需求,并展示了这种类型的Roflumilast分析(PDE-磷酸二酯酶4(PDE--4)COPD管理中的抑制剂将有助于指导政策决策和个人患者疗法。

有趣的是,BTS 2013上解决的主要主题主要是针对临床试验的,用于治疗各种肺部疾病,包括阻塞性睡眠呼吸暂停,囊性纤维化,COPD和特发性肺纤维化。我们期待一些正在进行的试验的结果,我们希望这些试验将有助于治疗和管理患有呼吸系统疾病的患者。这些条件非常重要,我们热衷于发布有关这些主题的研究进展,如果您有任何潜在的提交,请考虑我们,请与您联系bmcmedicineeditorial@biomedcentral.com

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