ISRCTN注册表在世界上轻松呼吸

在此博客中世界哮喘日我们看一下注册的哮喘研究和临床试验的选择ISRCTN注册表

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今年5月2日,世界哮喘日每年都由全球哮喘倡议组织(GINA)提高认识并改善世界各地的哮喘护理。五月也是美国哮喘和过敏基金会选择的美国国家哮喘和过敏意识月(美国(AAFA),因为这是哮喘和过敏患者的高峰季节。因此,现在是教育人们这些条件的最佳时机。为了标记这两种情况,让我们看一下注册的一些哮喘研究和临床试验ISRCTN注册表.

An introduction to asthma

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A reliever inhaler
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哮喘is a lung condition that causes breathing difficulties such as wheezing, breathlessness and cough. Unfortunately, there is currently no cure but there are treatments to keep the symptoms under control. The most common treatments are reliever and preventer inhalers. Reliever inhalers contain a medicine called a short-acting beta2-agonist and are used to relieve symptoms quickly. Preventer inhalers contain inhaled steroid medication and are used several times a day to prevent symptoms occurring.

新设备

哮喘can usually be controlled with these inhalers, but for some patients symptoms aren’t well controlled, so further treatments, including new devices, are in the pipeline.

已经开发了温度控制的层流气流(TLA)或AIRSONETT®设备,以过滤哮喘患者卧室中的空气,从而去除过敏颗粒以使其肺在一夜之间“休息”。该设备正在测试激光英国的研究(协议发表在Trials)。

CPAPdevices which are used to treat obstructive sleep apnea could also have a beneficial effect on asthma

And a学习来自皇家维多利亚医务室Freeman Hospital(UK) looks at whether continuous positive airway pressure (CPAP)用于治疗阻塞性睡眠呼吸暂停的设备也可能对哮喘产生有益的影响。

这样的设备有一天能像谦卑的吸入器一样普遍存在哮喘治疗的一部分吗?

哮喘发作

有时,哮喘症状会逐渐或突然变得更糟。这称为哮喘攻击。严重的攻击可能需要医院治疗,在极端情况下,甚至可能导致死亡,因此对于更严重的哮喘患者来说,非常需要新的治疗方法。

例如,有一种新型的药物ed omalizumab (brand name Xolair) that is given as an injection to prevent severe asthma attacks triggered by allergies. Its effects on the on the body’s immune system are currently being assessed in theSoMOSA研究的基础南安普敦综合医院(UK).

支气管热成形术可能会减少哮喘攻击,但尚不知道长期的好处和风险

Bronchial thermoplastyis another relatively new treatment that is very occasionally used for severe asthma. It’s a procedure that uses radio waves to heat the lining of the lungs, destroying some of the muscle tissue that constricts (gets narrower) during an asthma attack. It was tested in a multicenter学习逃离格伦菲尔德医院(UK). There’sevidencesuggesting that this procedure may reduce asthma attacks but the long-term benefits and risks are not yet known, and there’s a small risk it could even trigger an asthma attack and other complications.

目前,当哮喘症状无法通过吸入器控制良好时,目前都使用这两种新疗法,但是哮喘症状也可以通过改变生活方式来控制吗?

Diet and exercise

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补品
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除了传统的药物治疗外,还在测试饮食补充剂 - 研究人员Nottingham Trent University(UK) have looked at whether takingomega-3多不饱和脂肪酸益生元补充剂help patients with asthma caused by exercise. Regular exercise is of course important and helps to control asthma as it increases lung capacity. This学习在Chung-Shan医科大学医院(台湾)研究了定期运动是否可以帮助患有哮喘儿童。

Digital interventions

与生活的各个领域一样,互联网正在进入哮喘治疗,从一个简单的网站来促进哮喘自我管理葡萄干研究(协议发表在Trials), to an asthma social network called哮喘.

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There’s an app for that
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Participants in this学习atNottingham Respiratory Research Unit(UK) have been given a plastic casing to put on their inhaler which sends data on their usage back to the study investigators via the participants’ smartphones. It is hoped that this will be a better way of assessing adherence to treatment than the old methods of questionnaires and prescription counting.

精神高于物质?

There are also treatments addressing asthma from a mental health perspective. Mindfulness is a type of meditation that’s been used to treat conditions such as anxiety and depression, and it’s now being tested to see whether it can improve asthma patients’ quality of life.

Mindfulness meditation
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Researchers at the南安普敦大学(UK) have tested traditional weekly group sessions of mindfulness training in this学习,并且刚刚注册了学习using Headspace, a mindfulnessappwebsite. This study involves 30 days of 10-minute practices that can be done whenever it’s convenient for the patient.

类似的话,这个学习atJagiellonian大学医学院(波兰)正在测试音乐疗法是否可以帮助改善哮喘患者的身体症状和心理健康。这涉及听音乐治疗师每天住院一次的30分钟放松音乐,除了学习呼吸技术等标准治疗外。

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全球倡议对哮喘(吉娜)

带回家的消息

每隔十秒钟,英国的某人就会有潜在的威胁生命的哮喘攻击,每天三人死亡。如果您想帮助找到治疗哮喘但没有时间进行随机对照试验,请确保去大哮喘烘焙销售今天 - 售出的每个蛋糕都将有助于为慈善机构筹集资金英国哮喘.

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One评论

Andrew

你说不能治愈,但是我的哮喘病已经治愈。

I was diagnosed with asthma for the first time at age 12 when I had a bout of not being able to breathe.

From ages 12-46, I always had an inhaler with me (albuterol) for rescue purposes, and for use prior to any exercise. I typically had more issues around spring allergy time, and fall ragweed time, and several times a year went through week-long “bad” episodes when I had albuterol going around the clock, in later years sometimes with advair as well.

当我只有46岁的时候,我从饮食中掉下了乳制品 - 当时唯一的饮食变化。除了减掉几磅外,几个月后,我意识到几个月来没有呼吸问题。

事实证明,这种变化是永久的。现在已经三年了,我没有任何问题。甚至季节性过敏也消失了。我没有任何(任何种类的)。就我而言,我已经治愈了。

I’m not sure what about dairy was causing asthma, but it may simply be that I was allergic and that it contributed to the total allergy load on my body. So much so that when the key trigger (dairy) was removed, smaller contributors – e.g., the high pollen counts of spring and fall here in the mid-Atlantic – no longer had any impact.

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