对于诺贝尔委员会来说，这是忙碌的一周。所有这些都在打电话，让人们知道他们赢得了科学上最负盛名的奖项。

周一，发展生物学家约翰·古顿（John Gurdon）和山内卡（Shinya Yamanaka）接到了他们各自的电话。Physiology or Medicine” committee for their pioneering work on cellular reprogramming. And if you’re wondering how it feels to win such a prize, Yamanaka is报告通过说明：

“I don’t know how I am going to celebrate yet. I think I just need a beer.”

这将是当之无愧的。但是到底是为了什么？

诺贝尔议会已正式颁发了奖项“因为发现成熟细胞可以重新编程以变得多功能”，从接受者进行了大约40年的研究，但回顾性地构成了一个优雅的发展圈子。”

古顿的工作于1962年出版，推翻了专业单元格不变的时间，固定在其特定任务中的时间。通过从青蛙的肠道中去除成熟细胞的核并用卵形细胞的核交换，古尔登能够证明所有细胞核都包含必要的信息来构建整个生物体，然后这些初始卵细胞成熟成完全成年的青蛙。

In essence this work demonstrated that, far from being specialised satchels of information, cell nuclei were more akin to Mary Poppins-like无底地毯袋，充满了从头开始建立生物体的所有基因组指示。

当时这项工作于1962年出版，，，，Yamanaka’s研究电磁制动技术可被视为一个小于yonic, as he was born that very same year. His findings complemented beautifully those of Gurdon’s frog cell work by discovering the genetic switches that needed to be turned on to reverse this developmental process, and change fully mature specialised cells into blank slates – the pluripotent stem cells.

因此，今年的奖项遵循或发展 -授予仅仅几年前，马丁·埃文斯（Martin Evans），，，，Mario R. Capecchi和Oliver Smithies“for their discoveries of principles for introducing specific gene modifications in mice by the use of embryonic stem cells”，简洁地说明摘要图由诺贝尔议会制作。

Nobel’s do not come easy, and each recipient rightly has a powerful scientific pedigree. Among the many papers that paved the way to the prize, theBMC系列很高兴能够通过这项获奖作品同时发表Shinya Yamanaka的一些文章。发表的两篇文章BMC Developmental Biology通过特征来应对类似的基础胚胎干细胞特异性基因和多能性的调节，后者在《期刊》中接受了开创性论文的前几天出版细胞。

Indeed, it is gratifying to see Nobel-prize winning support for open access publishers, however brief, with another handful of papers published by the same group inPLOS ONEa few years later.

全部巨大的潜力该领域的干细胞研究港通常被认为是有争议的，因此近年来诺贝尔学院为这项工作如此大胆的支持是令人振奋的。可悲的是，消极的话语在很大程度上是由政治而不是科学助长的，它并没有逃脱出某些人的通知，即该奖项的宣布几乎是偶然的漫画时机with that of U.S. congressman and member of the House Science Committee Paul Broun announcing that such work was “谎言，直接从地狱的坑中”。

In such a sensitive climate, we feel that publishing openly is crucial.

如果今年奖中强调的作品可以采取一些小方法，以进行改进和合理的辩论，围绕这项研究的医学改进潜力，那么该学院将选择不错。如果Shinya Yamanaka和John Gurdon碰巧正在阅读此博客BMC系列will be delighted to buy them that beer.