Helminth parasites, or parasitic worms, cause severe disease in grazing ruminants. Anthelmintic drugs are frequently used to control these infections, but this has resulted in the emergence of anthelmintic-resistant (AR) helminth populations. AR has been detected in all major helminth species across Europe and globally and threatens effective control of parasitic infections.

成本动作组合 - 反刍动物的驱虫抗药性– is a European based working group that aims to advance research on the prevention of anthelmintic resistance (AR) in helminth parasites of ruminants in Europe and disseminate current knowledge amongst stakeholders.

第三次联合工作组和管理委员会会议在27个^Th-29^ThAugust 2019 at Het Pand situated in the historical center of Ghent, Belgium. 125 participants from 31 countries and 5 continents attended the three-day meeting. Key opinion leaders and specialists discussed their research and innovations for sustainable helminth control with the central theme being “Anthelmintic resistance in ruminants: Who cares?”. This topic was addressed through four main themes with keynote and oral presentations.

主题1：诊断驱虫阻力的影响

“抗菌素抵抗（AMR）在全球范围内是最重要的社会挑战之一，经济学在打击抗菌抗药性方面起着重要作用。”Jarkko Niemiof芬兰自然资源学院。Although AR may be considered part of the bigger AMR problem, it should not be confused with antibiotic resistance as the involved pathogens, drugs, impacts, and mechanisms are different. The financial impacts of AR to farming can nevertheless be substantial.

主题2：可持续寄生虫控制

Everybody has a role to play in sustainable parasite control

“每个人都在可持续寄生虫控制中起着作用，” Gustavo Sabatini说Boehringer-ingelheim动物健康。The pharmaceutical industry has an important role in directing investments towards the development of efficacious parasite control solutions that are both safe to the environment and food consumer. If every stakeholder plays its role accordingly, it will be possible to extend the lifetime of current antiparasitics with negligible harm to the environment and, at the same time, to develop the solutions for sustainable and effective parasite control programs in the future.

主题3：增强跨大西洋研究

“考虑影响AR的当前现场测试结果和解释的许多因素[粪便减少测试]明显的,一个简单的协议导致to significant variation between test outcome”, said雷·卡普兰（Ray Kaplan）of佐治亚大学， 美国。雷领导一组专家制定新的AR现场诊断指南。他建议应遵循单独的程序进行现场和研究使用。

主题4：保留吸毒功效

Deborah Maxwell ofParabosssaid that “In Australia, they have eight regional programs based on a cohesive set of anthelmintic resistance management principles that are adapted to regional conditions”. Adapting grazing management results in immediate reductions in the need to use anthelmintics, while genetic breeding for sheep resistance has not given clear results so far.

A session was also devoted to young scientists to report on their short-term scientific missions (STSM). Six young scientists had the opportunity to present the outcome of their STSM.

“This experience was important for my personal and scientific growth because it was a great opportunity to learn and improve techniques for the diagnosis of worm infections in cattle.” – Alessandra Amadesi, University of Naples Federico II, Italy

“在此STSM期间获得的知识和技能使我能够向我们的实验室介绍新的驱虫抗药性诊断方法” - 波兰华沙的Marcin Mickiewicz

到目前为止，组合取得了什么进展？

在中点欧洲科学技术合作（成本）行动，联合在实现其实现方面取得了长足的进步aims。To date, 32 countries are part of the action with 180 working group members, with nearly 40% of participants being early-career researchers. Fourteen STSMs have been completed so far involving 12 countries. Two successful training schools have been held on advances in diagnosis of helminth infections and AR, and the socio-economic aspects of helminth infections and AR. To date, COMBAR continues to disseminate information to the veterinary community and has published five scientific articles, including two key-opinion papers “牲畜掌舵研究中的100个问题” and “Control of helminth ruminant infections by 2030“。