白血病分析
Leukemia – cancer that usually starts in the bone marrow and results in large numbers of abnormal white blood cells – currently affects around327,000人in the US.
受白血病影响者的总生存率已有四倍over the last 50 years, thanks to the development of effectivetreatments。近年来，基因表达分析已成为检测诊断和预后生物标志物的有效工具，以帮助指导白血病患者的临床决策。
In a学习出版于BMC Bioinformatics, Erdogan Taskesen and colleagues from the代尔夫特生物信息学实验室investigated whether using gene expression and DNA methylation profiling together can improve the detection of different subtypes of acute myeloid leukemia (AML). The authors showed that using these two profiling techniques together improved prediction of molecular abnormalities in AML compared with using either alone.
Molecular profiling of leukemia is explored further in a评论文章出版于Journal of Hematology and Oncology，维罗妮卡·巴拉蒂（Veronica Balatti）et al.reviewed the roles of microRNAs in the development and progression of chronic lymphocytic leukemia, and discuss the potential for identifying new biomarkers and treatment approaches.
Molecular understanding of breast cancer
microRNAare involved in many types of cancer, and recentresearch出版于Genome Medicineprovides further evidence for their role in protein deregulation in breast cancer.
奥斯陆乳腺癌研究联盟的作者创建了一张microRNAS和蛋白质之间相互作用的图，这表明几种microRNA会在乳腺癌中解除蛋白质的表达，因此可能与疾病的发病机理有关。
While molecular subtyping is used in the breast cancer clinic to guide treatment decisions, increasingevidence表明该疾病比以前想象的要复杂，并且需要提高对遗传亚型的理解以建立更多个性化的治疗方法。
To address some limitations of subtyping techniques in current use, Sylvia Plevritis and colleagues presented a新的方法for gene centering – a method used to center gene expression values in a particular cohort prior to molecular subtyping.
该研究发表在Breast Cancer Research，表明与标准居中技术相比，一种亚组特异性的核心方法可以使更准确的疾病分类。这些发现可用于告知乳腺癌分类并改善未来的治疗结果。
Better reporting of research
Many studies in biomedical research involve the use of bioresources – collections of biological samples with associated data – and it is important that the use of such resources is reported in a standardized way.
In a guideline article published inBMC Medicine, Elena Bravo and colleagues present眼镜蛇,first guideline to introduce standardized citation of bioresources in scientific literature.
In aneditorial出版于试验,道格·奥特曼（Doug Altman）牛津大学从研究文章中讨论了结构化报告的重要性，突出了创新方法，用于对研究方法和关键发现进行更结构化报告。
Alcohol risks
酗酒长期与adverse health effectsincluding depression, cancer, and heart disease, but the consumption of some alcohol in moderation has also been linked to health benefits.
In aresearch article出版于关节炎研究与治疗, Stella Muthuri and colleagues from Nottingham University investigated the association between alcohol consumption and osteoarthritis (OA). The authors found that while beer consumption is a risk factor for knee and hip OA, wine has a negative association with knee OA.
虽然尚不清楚葡萄酒在OA中明显保护作用的机制，但这些结果强调了避免该患者组中过量啤酒消费的重要性。
为了减少与饮酒过量相关的健康风险，重要的是要了解不同文化中饮酒的态度。为了解决这个问题，基于问卷学习出版于BMC公共卫生研究了尼日利亚的性别特定性别使用饮酒模式。
结果表明，男人认为酒精是“对男性有益的”，而妇女认为酒精“不歧视性别”，男性和女性都应喝酒，表明酒精消费的性别结构如何为男女带来风险。
康复和恢复的进步
Increasing evidence suggests that early mobilization is important to improve recovery in the intensive care unit (ICU) and reduce ICU-acquired weakness.
In a学习出版于重症监护,TEAMresearch program revealed that early mobilization is not common across ICUs in Australia and New Zealand despite physiotherapists being available, and more than 50% of patients are discharged with ICU-acquired weakness as a result. The authors conclude that early mobilization trials should be designed to help improve patient outcome.
Focusing on movement rehabilitation post-stroke, authors from theUniversity of North Carolina at Chapel Hillhave developed a neuromechanics-based powered ankle exoskeleton. In afeasibility study出版于神经工程和康复杂志，发现外骨骼可增强踝关节运动，表明其在中风中恢复的患者中提高踝关节功能的潜力。
此博客中讨论的所有文章都是开放访问的，并且可以在www.biomedcentral.com。
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