Cognitive aging in the brain affects all of us, and is the focus of anew thematic serieslaunched inAlzheimer’s Research & Therapy.

Aging can be associated with relatively little cognitive decline. But for some, it can lead to mild cognitive impairment (MCI), or cause a severe loss in cognitive function and result in dementia. Alzheimer’s disease (AD) is the most common form of dementia in older people and is characterized by behavioural disorders and a progressive decline in memory function.

In recent decades, there have been significant advances in our understanding of cognitive aging, but little advance in translating this knowledge into therapeutics. The AD epidemic is a looming crisis and there is an urgent need for new therapies to delay or prevent symptom onset and progression.

In the launch of a thematic series on ‘Cognitive Enhancers for Aging and Alzheimer’s disease’, guest edited byDr Howard Fillit(ADDF, USA), new approaches to drug discovery and development for therapeutics to treat cognitive aging are presented.

María Javier Ramírez (University of Navarra, Spain) opens the seriesreviewing evidence supporting the cognitive effects of 5-HT₆receptor compounds. The 5-HT₆receptor is involved in affective disorders, anxiety and depression, epilepsy, and obesity. The receptor also has a role in learning and memory processes so there is significant interest in the potential of 5-HT₆-targeted compounds as powerful therapeutic candidates in AD.

In a second article, Allan Levey (Emory University, USA) and colleagues discusstreatments that target norepinephrine in MCI and AD. Increasing norepinephrine transmission may have the potential to delay or reverse AD-related pathology, especially if novel noradrenergic-based therapies are initiated during MCI. Evidence for noradrenergic-based therapies is reviewed, as well as the promising results seen in animal models of AD and the potential of translating this to early-phase clinical trials in humans.

This special series will present a collection of commissioned reviews and opinions written by leaders in the field. Upcoming contributors include杰里·鲁克（Jerri Rook）(Vanderbilt University),艾米Arnsten(Yale),Gerhard Koenig(En Vivo Pharmaceuticals) and约瑟夫·科伊尔（Joseph Coyle）(Harvard).

We also welcome research manuscripts that present new therapeutic approaches in the field of cognitive aging.

If you would like to enquire about the suitability of a study for consideration, please emaileditorial@alzres.com. Otherwise pleasesubmit onlineand indicate in your covering letter that you would like the article to be considered for the cognitive enhancers series.

For further information about the journal, please visit thewebsite, orcontact usfor enquires about the special series. To access all subscription content; including peer-reviewed reviews, commentaries and viewpoints, register for afree online trialto the journal and sign up forarticle alerts.